While the role of gut microbiota in health has been demonstrated, deciphering the involvement of individual bacterial species in diseases with unmet clinical needs represents a major research interest. Over the last decade, DP8α regulatory T cells (Tregs) have been identified to respond toand protec...
作者单位信息
Nantes Université, Univ Angers, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Nantes, France.
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated systemic disease that causes organ-specific inflammation and fibrosis patterns and also frequently has tumor-like effects. In the pancreaticobiliary setting type 1 autoimmune pancreatitis (AIP1) and IgG4-related cholangitis (IAC) are...
作者单位信息
Institut für Molekulare Onkologie und Stammzellbiologie, Uniklinik Ulm, Ulm, Deutschland. alexander.kleger@uni-ulm.de.
Cholesterol metabolic reprogramming is an emerging vulnerability in cancer, yet clinical progress has been limited by a lack of druggable targets. Here, we identify the sterol-sensing domain (SSD) of SCAP as a target in gastric cancer (GC), with multi-omics confirming tumor-specific SCAP overexpress...
作者单位信息
Center for Innovative Drug Research, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Targeting the ATX-LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways.
Human precision-cut liver slices (hPCLS) are widely used to study liver physiology and disease, but their short lifespan limits long-term functional studies and drug testing. Here, we describe an optimized ex vivo culture system, hPCLS-EV (Extended Viability), that maintains tissue viability, cellul...
作者单位信息
Institute of Pathology, University Hospital Basel, Basel, Switzerland.
Ductular reaction (DR) is a hallmark of biliary atresia (BA), but its underlying mechanisms remain unclear. In this study, we identified an expanded NCAM1EpCAMhepatic progenitor cells (HPCs) as the predominant DR-related cell cluster using single-nucleus RNA sequencing, and NCAM1EpCAMHPC-derived org...
作者单位信息
Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
OBJECTIVES: Mounting evidence suggests that ferroptosis is closely involved in the development of severe acute pancreatitis (SAP). This study aimed to investigate the association between abnormal lipid metabolism and ferroptosis and elucidate the role of the Keap1/Nrf2/SLC7A11/GPX4 pathway in pancre...
作者单位信息
Intensive Care Unit, Department of Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, 530021, Guangxi, China.
As the resident tissue macrophage of the liver, Kupffer cells (KCs) play an important role in homeostasis and tissue support. However, current in vitro liver models often ignore the contribution of these KCs towards the proper response and function of the tissue. This is especially relevant when we...
作者单位信息
Innovations in Food and Chemical Safety Programme (IFCS), A*STAR, Singapore, Singapore.
Intestinal fibrosis presents a major clinical challenge in Crohn's disease (CD) due to the lack of effective pharmacological interventions. The underlying mechanisms of intestinal fibrosis remain largely elusive. Reanalysis of the single-cell RNA-seq data from full-thickness CD tissue identifies a d...
作者单位信息
Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
Foliar-Applied EDTA-Zn Reduces Grain Cd Content inL. Grown in Alkaline Fields with Cd Contamination by Regulating Vascular Bundle-Mediated Transport and Sequestration of Cd in Nodes and Rachises.
Authors: Ding Hao Li, Gui Li Hua, Pei Pei Gao, ... Wen Ju Liu
Foliar application of zinc (Zn) compounds is a promising strategy for mitigating cadmium (Cd) accumulation in wheat grains in pot experiments. However, its inconsistent field efficacy, especially in alkaline soils with long-term Cd contamination, poses a unique challenge. Herein, field experiments a...
作者单位信息
State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding 071000, Hebei, China.
Lactate and β-hydroxybutyrate (βHB), once regarded mainly as metabolic byproducts or alternative fuels, are now increasingly recognized as redox-active metabolites that regulate energy partitioning, mitochondrial function, and adaptive stress responses. Here, we propose a unifying framework in which...
作者单位信息
Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China. Electronic address: dhlin@xmu.edu.cn.
Bile duct injuries following blunt abdominal trauma are rare complications that may go unnoticed during emergency care. Due to edema and inflammation, these injuries can lead to bile duct obstruction, resulting in dilation of the hepatobiliary system and potential perforations. Such cases are medica...
作者单位信息
Department of Medicine, Faculty of Medicine, University of São Paulo, São Paulo, BRA.
Bisphosphonates (BPs) are the most widely used anti-resorptive agents and first-line drugs for managing bone-related diseases, such as osteoporosis, Paget disease of bone, and bone metastatic cancer. BPs are known to inhibit osteoclasts' functions, and recent studies have highlighted the importance...
作者单位信息
The Shapiro Family Laboratory of Viral Oncology and Aging Research, UCLA School of Dentistry, Los Angeles, CA, USA.
BACKGROUND: Acute pancreatitis (AP), a common gastrointestinal emergency, lacks specific treatments. β-elemene (ELE), a sesquiterpene derived from Curcuma phaeocaulis, has attracted attention for its anti-inflammatory and immunomodulatory properties beyond its known antitumor effects. However, its p...
作者单位信息
Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
is a key member of the gut microbiota and plays important roles in host metabolism and health. In the colon,extracts nutrients from oligosaccharide-rich mucin glycans that comprise the mucosa. However, this environment is complex and shaped by dietary inputs, microbiome metabolism, and mucin glycan...
作者单位信息
Department of Bioengineering, Rice University, Houston, TX, USA.
Addiction is a chronic and relapsing disorder that affects millions of people worldwide; nonetheless, currently available FDA-approved treatments are limited in number and effectiveness. In past years, the gut-brain axis has emerged as a key modulatory factor associated with different psychiatric di...
作者单位信息
Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Although reprogramming tumor-associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce. Inspired by the pro-inflammatory M1-like response triggered by trypsinogen in pancreatitis, trypsinogen as a novel macrophage reprogrammer...
作者单位信息
Department of Radiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Metabolic reprogramming is a hallmark of cancer, yet the critical drivers and mechanisms in hepatocellular carcinoma (HCC) remain incompletely understood. Through a metabolism-focused CRISPR screen, we identified phosphomevalonate kinase (PMVK), a mevalonate pathway enzyme, as a key regulator of HCC...
作者单位信息
Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
Inflammasomes are cytosolic multiprotein complexes that activate caspase-1, which promotes inflammation and host defense by driving cytokine maturation and pyroptosis. Several studies reported that caspase-1 selectively drives cytokine maturation without concomitant pyroptosis in neutrophils, yet th...
作者单位信息
Immunology Translational Research Programme, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore.
Metastasis remains a major therapeutic challenge in colorectal cancer, highlighting an urgent need to elucidate its underlying molecular mechanisms. In this study, an in vivo screening system integrating genome-wide short hairpin RNA library and next-generation sequencing identifies six candidate me...
作者单位信息
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Colon cancer remains a formidable therapeutic challenge due to its high malignancy and limited treatment options. To overcome this, we develop a multifunctional nanoplatform (HILA) using hollow mesoporous manganese dioxide (HMnO) to co-load lactate oxidase (LOX) and the photosensitizer indocyanine g...
作者单位信息
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmaceutical Sciences, Guizhou International Science & Technology Cooperation Base for Druggability Research of Natural Medicines, The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, the Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University, Guizhou, China.
Integrating probiotics with functional nanomaterials to disrupt the cycle of gut microbiota dysbiosis and reactive oxygen species (ROS) overload is an emerging therapeutic strategy for inflammatory bowel disease (IBD). However, simplistic combinations of therapeutics often result in spatiotemporal m...
OBJECTIVE: The present study investigated whether acupuncture alleviates CUMS-induced depressive-like behaviors in rats and examined whether the Glu/mGluR3/BDNF signaling pathway is associated with these effects, identifying mGluR3 as a potential molecular substrate rather than a confirmed causal me...
作者单位信息
Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China; Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, PR China; Shenzhen Research Institute of Xiamen University, Shenzhen, PR China.
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare lung disease caused by autoantibodies targeting granulocyte-macrophage colony-stimulating factor (GM-CSF). Although serum GM-CSF autoantibody levels are markedly increased in aPAP patients, total antibody titer does not correlate with diseas...
作者单位信息
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
BACKGROUND: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction, with some recommended treatments targeting brain-gut axis dysfunction.
OBJECTIVE: To compare relative efficacy of gut-brain neuromodulators and brain-gut behaviour therapies in IBS.
DESIGN: Network meta-analysis sea...
作者单位信息
Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang Province, 310009, China.
Acute pancreatitis (AP) concurrent with acute kidney injury (AKI) remarkably elevates the risk of adverse outcomes in affected individuals. Abnormal serum magnesium concentrations have been linked to AKI development across diverse patient populations; however, the prognostic significance of serum ma...
作者单位信息
The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, China.
IFNG (interferon gamma)-activated macrophages contribute to accelerated clearance of platelets and excessive secretion of inflammatory cytokines in immune thrombocytopenia (ITP). In this study, we identified two distinct subpopulations of activated macrophages: phagocytic macrophages (M[IFNG]), whic...
作者单位信息
Department of Hematology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.