Beneficial effects of the gut commensal Agathobacter rectalis (Ar) are reported in diseases, yet its role in colorectal cancer (CRC) remains unclear. Here, metagenomic analysis revealed consistent fecal Ar depletion across CRC cohorts. Inmice, Ar inhibited colon tumorigenesis, reducing tumor number...
作者单位信息
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Fission increases the number of crypts in the intestine during neonatal growth and also restores crypt density after injury by bifurcation of a pre-existing parent crypt into daughter crypts. While fission is typically symmetric in healthy crypts, it is more asymmetric in diseases, and the relations...
作者单位信息
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, USA.
Acute necrotizing pancreatitis is a severe condition associating with high morbidity and mortality. In most cases, supportive therapy is the only available therapeutic option. Herein, we report a case of a 29-year-old male who presented with severe acute necrotizing pancreatitis caused by hypertrigl...
作者单位信息
Department of Cardiology and Cardiovascular Research Institute Basel, University Heart Center Basel, University Hospital Basel, Switzerland. felix.goetzinger@usb.ch.
BACKGROUND AND AIMS: Acute pancreatitis (AP) is an inflammatory disease with a wide range of severity. Disruption of the intestinal barrier and translocation of gut flora increase the risk of infectious complications. Our study evaluates the impact of infections on in-hospital outcomes among admitte...
作者单位信息
Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai, NY, USA. ishakohli689@gmail.com.
Immune checkpoint blockade for hepatocellular carcinoma (HCC) is frequently limited by the extracellular matrix (ECM). Through transcriptomic profiling, we identify that acquired anti-PD-1 resistance in HCC models is closely associated with prominent Fibronectin 1 (Fn1) upregulation within the tumor...
作者单位信息
Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, People's Republic of China.
Department of Gastroenterology, Inflammatory Bowel Disease Center, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: mushougongx@zju.edu.cn.
Cancer progression is systemically influenced by distant organ dysfunction induced by primary tumors, yet how long-distance tumor-organ crosstalk regulates antitumor immunity remains unclear. Here, we identify host metadherin (MTDH) as a critical regulator of tumor-induced immunosuppression and meta...
作者单位信息
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ 08544, USA.
Diabetic ketoacidosis (DKA) is a life-threatening metabolic emergency that may be accompanied by severe hypertriglyceridemia (HTG), particularly in patients with poorly controlled type 1 or 2 diabetes mellitus. Marked HTG is a well-recognized cause of acute pancreatitis, while splenic vein thrombosi...
作者单位信息
Internal Medicine, New York City Health and Hospitals/Harlem Hospital Center, New York, USA.
Acute Necrotizing Pancreatitis Secondary to Adhesive Afferent Loop Syndrome Six Years After Total Gastrectomy With Roux-en-Y Reconstruction: A Case Report.
Authors: Emilly Hanay M Santos, Ana Carolina B Blitzkow
Acute pancreatitis is an uncommon presentation of afferent loop syndrome, and progression to necrotizing pancreatitis is rarely described in the literature. A 65-year-old man presented with severe epigastric pain, nausea, and bilious vomiting six years after total gastrectomy with Roux-en-Y reconstr...
作者单位信息
General Surgery and Digestive Surgery, Hospital de Clínicas Universidade Federal do Paraná, Curitiba, BRA.
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies worldwide because most patients are diagnosed at advanced stages when curative treatment is no longer feasible. Metabolomics has emerged as a promising strategy for identifying biochemical altera...
作者单位信息
Department of Microbiology School of Medicine, Shahid Beheshti University of Medical Sciences Tehran Iran.
High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and diabetes, yet the underlying mechanisms, especially at the specific organ level, are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructose breakdown in the...
作者单位信息
Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, School of Medicine, University of California Irvine, Irvine, CA, USA.
Sepsis-associated liver dysfunction is a life-threatening condition with a high mortality rate and no mechanism-based therapy. In this study, we identify the cross-linking enzyme transglutaminase 2 (TG2) as a driver of liver inflammation by activating macrophages in a mouse model of sepsis. Pharmaco...
作者单位信息
Department of Intensive Care Unit, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Gulou, Nanjing 210008, China.
Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol usin...
作者单位信息
Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Long-acting oral delivery of macromolecular therapeutics remains difficult, as most oral delivery devices focus on improving gastrointestinal absorption but do not adequately address sustained drug release and frequent dosing. In parallel, many gastric-retentive systems rely on nondegradable structu...
作者单位信息
Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
Peroxisome proliferator-activated receptor gamma (PPARγ) is a key transcriptional regulator of genes mediating adipogenesis (fat-cell differentiation), and lipid storage in several cell types like hepatocytes. As such, its regulation is crucial for cell and organismal physiology. Indeed, PPARγ's act...
作者单位信息
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder and progresses through distinct pathological stages whose specific drivers remain unclear. Here we show that cytosolic prostaglandin E synthase (cPGES) drives MASLD progression in a cell-typ...
作者单位信息
Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China. Electronic address: dandanzhong@xzhmu.edu.cn.
Increased perinatal levels of CXCL9, GZMB and MMP-10 are associated with pediatric-onset IBD: A nested case control study within a population-based birth cohort.
Authors: Olle Grännö, Daniel Bergemalm, Benita Salomon, ... Johnny Ludvigsson
BACKGROUND & AIMS: Acute pancreatitis (AP) is a life-threatening inflammatory disease with a rising incidence in which intestinal barrier dysfunction and bacterial translocation contribute to severe disease progression. Short-chain fatty acids (SCFAs), key microbial metabolites, have been linked to...
作者单位信息
Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China; Postdoctoral Innovation Practice Base, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
BACKGROUND & AIMS: Chimeric antigen receptor (CAR) T cell therapy for pancreatic ductal adenocarcinoma (PDAC) has been challenging, in part due to the paucity of tumor-specific cell-surface targets. Here, we explored the design feasibility and anti-tumor efficacy of CAR T cells recognizing the CA19-...
作者单位信息
Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Thermoneutrality accelerates a distinctive metabolic dysfunction-associated steatohepatitis phenotype in a diet-induced male mouse model with similarities to human disease.
Authors: Renata Leke, Jennifer Y Tan, Stephanie Ling, ... Bader Zarrouki
BACKGROUND & AIMS: Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent chronic liver disease characterized by steatosis, inflammation, and hepatocyte damage, with or without fibrosis. Robust preclinical models that represent the clinical features of MASH are critical for drug deve...
作者单位信息
Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: renata.leke@astrazeneca.com.
The Warburg effect, a hallmark of metabolic reprogramming, drives tumor progression, but its upstream regulation remains unclear. Using hepatocellular carcinoma (HCC) as a model, we identify TRIM32, an E3 ubiquitin ligase, as a potent activator of glycolysis that promotes malignancy. TRIM32 is upreg...
作者单位信息
Department of Hepatobiliary Surgery, The Second Qilu Hospital of Shandong University, Jinan, China.
A Comparative Evaluation of Fibrosis in Patients with and without Chronic Pancreatitis Undergoing Pancreatic Surgery.
Authors: Aida A Metri, Mahya Faghih, Elham Afghani, ... Vikesh K Singh
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association发现:2026-08-29出版:2026-08-27PMID:42660256DOI:10.1016/j.cgh.2026.08.015
BACKGROUND AND AIMS: Fibrosis is considered the gold standard for diagnosing chronic pancreatitis (CP) but has not been systematically studied across a large cohort of patients with and without pancreatitis undergoing different pancreatic surgeries.
METHODS: Demographic, clinical and radiologic dat...
作者单位信息
Division of Gastroenterology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
BACKGROUND: Cholangiocarcinoma (CCA) is a highly malignant cancer that develops in the bile ducts. Its incidence is particularly high in East Asian populations, but the underlying genetic factors remain unclear. To investigate potential risk factors for CCA, we conducted a Mendelian randomization st...
作者单位信息
Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Microbiome-based therapeutics have rapidly evolved into a transformative field at the intersection of infectious diseases, microbial ecology, and precision medicine.infection (CDI) represents the most extensively studied model, providing a framework for understanding microbiome-driven disease and ec...
作者单位信息
National Institute of Research and Development for Biological Sciences, Bucharest, Romania.
Cell competition in multicellular organisms has been shown to play a critical role during the development of organisms, cancer progression, and in the establishment and maintenance of tissue homeostasis. Various mechanisms of cell competition have been identified, including active elimination via me...
作者单位信息
Institute for Theoretical Physics, Department of Physics, Faculty of Science, Utrecht University, Princetonplein 5, Utrecht 3584 CC, The Netherlands.
Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β-glucan-BA (GLU-BA) is synthesized via one-step...
作者单位信息
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Secreted proteins are essential to modulate homeostasis in the extracellular space and facilitate communication to distal cells or tissues. Yet, the identity and functional importance of extracellular proteins in aging have been understudied. Here we use proximity labeling followed by quantitative p...
作者单位信息
Department of Genetics, Stanford University, Stanford, CA, USA.
Mitochondrial magnesium (Mg) is essential for cellular metabolism and bioenergetics, yet the mechanisms governing its transport remain poorly understood. Although MRS2 constitutes the pore of theMgchannel, the molecular machinery regulating its function is unknown. Here, unbiased proteomics identifi...
作者单位信息
Center for Mitochondrial Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
BACKGROUND AND AIMS: Tumors actively remodel the tumor microenvironment (TME) to foster therapy resistance. However, the underlying mechanisms remain poorly defined. This study aims to characterize how colorectal cancer (CRC) cells drive TME remodeling to promote radioresistance.
METHODS: A radiore...
作者单位信息
Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
OBJECTIVE: We previously validated a short endoscopic test with pancreas fluid enzyme activity in pediatrics and young adults. We assessed the role of pancreatic fluid enzyme activity as a candidate to address the lack of a diagnostic biomarker for chronic pancreatitis (CP).
METHODS: In this pilot...
作者单位信息
Department of Internal Medicine, University of Kentucky, College of Medicine, Lexington, KY 40536, USA.