PUBMED DIGEST WATCHER

消化基础研究文献雷达

每天自动追踪 PubMed RSS 最新文献,聚焦消化系统、肝胆胰、微生物组、免疫炎症、细胞死亡、类器官、动物模型和多组学研究。

已缓存文献
439
最近更新时间
2026-04-29 08:24:14 UTC+8
存储方式
Supabase 数据库

支持手动抓取、按订阅源过滤、搜索筛选,以及快速一览表与详细卡片切换。

UTC+8

近期重点文献

优先展示今日新增,近期高分文献补足

仅展示 JCR Q1/Q2、IF > 3 的重点文献

Proceedings of the National Academy of Sciences of the United States of America发现 2026-04-29出版 2026-05-05Score 9IF 9.1JCR Q1中科院 综合性期刊1区

Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.

本研究发现,胰腺导管腺癌中线粒体支架蛋白Mic60水平降低导致线粒体双链RNA释放,通过RIG-I/TLR3通路激活NFκB介导的炎症反应,从而促进肿瘤生长,并为特定患者提供了潜在的治疗靶点。

  • Mic60低表达的胰腺癌患者表现出炎症增强、NFκB活性升高和TNFα产生增加
  • 结构缺陷的线粒体释放双链RNA,激活TLR3/RIG-I传感,驱动NFκB基因表达并促进肿瘤增殖

相关性:从摘要看,该研究揭示了线粒体损伤(如Mic60缺陷)通过释放双链RNA激活固有免疫炎症通路(如TLR3/NFκB)的机制,这为理解胰腺炎中线粒体功能障碍、炎症放大和细胞死亡提供了潜在借鉴,但直接针对急/慢性胰腺炎的证据有限。

线粒体双链RNARIG-I/TLR3通路NFκB炎症胰腺导管腺癌Mic60蛋白肿瘤微环境

Pancreatitis-related; mechanism keywords; strong journal metrics

Cell reports发现 2026-04-29出版 2026-04-27Score 7IF 6.9JCR Q1中科院 生物学1区

GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.

本研究发现GLIS3标记的神经样祖细胞状态在胰腺导管腺癌中驱动转移,该状态与治疗后肿瘤再生程序相关。

  • 神经样祖细胞特征在正常胰腺损伤和再生中富集,并在PDAC治疗后出现
  • GLIS3是关键的NRP相关因子,促进克隆形成性、肿瘤生长和转移

相关性:研究揭示的胰腺损伤再生程序和炎症信号(如IL-1β)机制,可能为急性/慢性胰腺炎中的组织修复和炎症调控提供借鉴。GLIS3在再生中的作用或可关联胰腺炎后的纤维化或修复过程。

GLIS3神经样祖细胞胰腺导管腺癌转移再生程序IL-1β

Pancreatitis-related; strong journal metrics

International immunopharmacology发现 2026-04-28出版 2026-04-26Score 92026-04-28IF 4.7JCR Q1中科院 医学2区

Identifying cathepsin B as a key regulator of programmed cell death in acute pancreatitis.

本研究通过生物信息学分析和动物实验,鉴定出组织蛋白酶B(CTSB)是急性胰腺炎(AP)中程序性细胞死亡(PCD)的关键调控因子,并作为潜在治疗靶点。

  • 生物信息学分析筛选出CTSB为具有高诊断价值的枢纽基因,富集于PCD和炎症通路
  • AP小鼠模型中,多种PCD途径被激活,且胞质CTSB水平升高

相关性:该研究直接针对急性胰腺炎,揭示了CTSB在调控多种细胞死亡方式中的核心作用,为开发靶向CTSB的治疗策略提供了直接依据。其关于细胞死亡途径(如凋亡、铁死亡、焦亡)和炎症调控的机制,对理解急/慢性胰腺炎的发病机制具有重要借鉴价值。

组织蛋白酶B程序性细胞死亡急性胰腺炎生物信息学动物模型炎症调控

Pancreatitis-related; mechanism keywords; strong journal metrics

Journal of hepatology发现 2026-04-27出版 2026-04-24Score 42026-04-27IF 33.0JCR Q1中科院 医学1区

Tim-3 facilitates dendritic cell ferroptosis and impairs anti-tumor immunity in steatohepatitis-related HCC.

本研究揭示了在代谢相关脂肪性肝病相关肝细胞癌中,Tim-3通过促进树突状细胞铁死亡来抑制抗肿瘤免疫,并提出靶向Tim-3的联合治疗策略。

  • 高脂饮食重塑肝脏肿瘤免疫微环境,导致DC耗竭和CD8T细胞功能障碍,促进肿瘤进展
  • 在人脂肪性肝炎-HCC中,DC浸润和DC-CD8T细胞相互作用显著受损,且DC特异性Tim-3高表达与不良预后相关

相关性:从摘要看,对急/慢性胰腺炎研究的直接借鉴价值有限。然而,该研究揭示的免疫代谢检查点(如Tim-3)在调节免疫细胞(如树突状细胞)死亡(铁死亡)和炎症微环境中的作用,可能为理解胰腺炎中类似的免疫失调和细胞死亡机制提供间接参考。

Tim-3树突状细胞铁死亡脂质过氧化代谢相关脂肪性肝病肝细胞癌

mechanism keywords; strong journal metrics

British journal of pharmacology发现 2026-04-25出版 2026-04-22Score 6最近精选IF 7.7JCR Q1中科院 医学2区

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis.

本研究发现金属蛋白酶ADAM17在胰腺炎诱导的急性肺损伤中表达上调,并通过促进TNFα和sIL-6R的脱落加剧肺部炎症反应。

  • ADAM17在胰腺炎模型小鼠的胰腺和肺组织中表达上调
  • 靶向抑制ADAM17可减轻实验性胰腺炎相关的肺部炎症,并选择性减少其底物可溶性TNFα和sIL-6R的胞外脱落

相关性:该研究揭示了ADAM17在胰腺炎向多器官功能障碍(特别是急性肺损伤)进展中的关键作用,为开发治疗胰腺炎相关肺损伤的新靶点提供了直接依据。其机制涉及炎症介质脱落和巨噬细胞生物学,对理解胰腺炎全身并发症的炎症通路具有借鉴意义。

ADAM17急性胰腺炎急性肺损伤TNFαsIL-6R巨噬细胞

pancreatitis; pancreatic; inflammation

RSS 订阅源

当前订阅源

全部订阅

当前显示文献数

439

有作者信息

437

有作者单位

434

有 DOI

433

最近更新时间

2026-04-29 08:24:14 UTC+8

快速一览表 (439)

当前显示 30 / 439

页面最近更新时间:2026-04-29 08:24:14 UTC+8

日期期刊标题作者PMID操作

发现 2026-04-29

出版 2026-06-01(期刊卷期日期)

The Journal of experimental medicine
LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis.
José L Fachi, Tihana Trsan, Cristiane Sécca, ... Marco Colonna42048289
打开 PubMed

发现 2026-04-29

出版 2026-06-01(期刊卷期日期)

The Journal of experimental medicine
BACH2 controls ILC3 function via PPARγ-dependent mitochondrial metabolism.
Jianye Wang, Ying Wang, Gaoyu Liu, ... Jie Zhou42047686
打开 PubMed

发现 2026-04-29

出版 2026-06-01(期刊卷期日期)

The Journal of experimental medicine
Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection.
Jiseon Kim, Joseph R Dominguez, Seung Hyeon Kim, ... Ki-Wook Kim42048131
打开 PubMed

发现 2026-04-29

出版 2026-05-05

Proceedings of the National Academy of Sciences of the United States of America
Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.
Andrew T Milcarek, Minjeong Yeon, Camilla Esposito, ... Dario C Altieri42048448
打开 PubMed

发现 2026-04-29

出版 2026-05-05

Proceedings of the National Academy of Sciences of the United States of America
A Trojan horse pathogen breaking through partner-choice barriers in the insect gut.
Kota Ishigami, Seonghan Jang, Aoba Yoshioka, ... Yoshitomo Kikuchi42048464
打开 PubMed

发现 2026-04-29

出版 2026-05-05

Proceedings of the National Academy of Sciences of the United States of America
TLR1 deficiency associates with immune dysregulation and colitis.
Yusha Wang, Xu Han, Libo Wang, ... Qing Zhou42048460
打开 PubMed

发现 2026-04-29

出版 2026-05-05

Proceedings of the National Academy of Sciences of the United States of America
Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular-cholangiocarcinoma.
Lin Chen, Dalin Wang, Weidong Qin, ... Qichao Huang42048452
打开 PubMed

发现 2026-04-29

出版 2026-05-05

Proceedings of the National Academy of Sciences of the United States of America
Erythroferrone derived from osteoblasts regulates stress erythropoiesis.
Pinanong Na-Phatthalung, Gabrielle van Caloen, Marina Planoutene, ... Yelena Z Ginzburg42048446
打开 PubMed

发现 2026-04-29

出版 2026-04-28

Annals of African medicine
Comparative Study of the Prognostic Efficiency between Ranson's Criteria and Modified Computed Tomography Severity Index in Patients Diagnosed with Acute Pancreatitis.
A Naren Kumar, Chandan Sanga42047707
打开 PubMed

发现 2026-04-29

出版 2026-04-28

Blood advances
Endothelial Activation and Damage associated with Steroid-Refractory aGVHD is counteracted by Ruxolitinib.
Blanca De Moner, Julia Martinez-Sanchez, Silvia Escribano-Serrat, ... Maribel Diaz-Ricart42048573
打开 PubMed

发现 2026-04-29

出版 2026-04-28

Autophagy
Exploiting autophagy-targeting natural compounds for potential antimicrobial actions.
Seungwha Paik, Soohyun Um, In Soo Kim, ... Eun-Kyeong Jo42047332
打开 PubMed

发现 2026-04-29

出版 2026-04-28

Pancreas
Dietary Patterns Following an Episode of Acute Pancreatitis: a Post-hoc Analysis From the PAPPEI Multi-Center, Prospective Study.
Kristen M Roberts, Sasathorn Thongkhao-On, Stacey Culp, ... Phil A Hart42047302
打开 PubMed

发现 2026-04-29

出版 2026-04-27

Cell reports
GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.
Dennis Gong, Jimmy A Guo, Jennifer Su, ... William L Hwang42048185
打开 PubMed

发现 2026-04-28

出版 2026-12-31(期刊卷期日期)

Gut microbes
Sex modulates the long-term effects of delivery mode on microbiota-gut barrier crosstalk and colitis susceptibility in mice.
Bruna Maitan Santos, Jordi Estellé, Yuliaxis Ramayo-Caldas, ... Rebeca Martín42044680
打开 PubMed

发现 2026-04-28

出版 2026-04-28

Signal transduction and targeted therapy
Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer.
Xiaofan Guo, Yuxiao Liu, Tianchen Li, ... Jihui Hao42045172
打开 PubMed

发现 2026-04-28

出版 2026-04-27

Gut
The UK experience with hepatitis B immunoglobulin use following liver transplantation: wide variation in practice despite evidence supporting cost-effective HBIG-free prophylaxis.
Almuthana Mohamed, Maria Guerra Veloz, Lindsay Greenland, ... Ahmed M Elsharkawy42045019
打开 PubMed

发现 2026-04-28

出版 2026-03-01

Cureus
Recurrent Acute Pancreatitis Revealing Pancreatic Infiltration by CD20-Positive B-cell Lymphoma: A Diagnostic Pitfall in Extranodal Lymphoma.
Daniela Prado Escobar, Claudia Pedreira, Kian Memari, ... Peter Cohen42046631
打开 PubMed

发现 2026-04-28

出版 2026-01-01

Journal of inflammation research
Using the Phillygenin Ameliorates the Severe Acute Pancreatitis in Rats by Inhibiting TLR4/NF-κB Pathway.
Yiwen Sun, Shengze Li, Jiming Duan, ... Wenxing Li42046726
打开 PubMed

发现 2026-04-28

出版 2026-04-27

Digestive diseases and sciences
Chronic Pancreatitis: Role of Endoscopic Procedures.
Renan Prado, Arjun Chatterjee, Leandro Sierra, ... Prabhleen Chahal42043472
打开 PubMed

发现 2026-04-28

出版 2026-04-26

International immunopharmacology
Identifying cathepsin B as a key regulator of programmed cell death in acute pancreatitis.
Xiaozhou Xie, Yuchen Jia, Zheng Wang, ... Fei Li42044578
打开 PubMed

发现 2026-04-28

出版 2026-04-20

Immunobiology
Estrogen ameliorates Caerulein-induced inflammatory injuries and oxidative stress in acute pancreatitis via STAT3/PGAM1 signaling.
Weixi Shan, Wenyu Zhou, Ya Huang, ... Long Yang42044555
打开 PubMed

发现 2026-04-28

出版 2026-04-16

Diseases (Basel, Switzerland)
Neuromodulatory Interventions in Experimental Acute Pancreatitis: A Systematic Review of Rodent Studies.
Maxim Rantsev, Alexey Sarapultsev, Valeriy Chereshnev42041637
打开 PubMed

发现 2026-04-28

出版 2026-04-06

Advances in respiratory medicine
Stroke-Associated Pneumonia and Impaired Functional Recovery After Stroke: The Role of Nutritional-Inflammatory Factors.
Rongjian Feng, Chonggui Jiang, Yan Yang, ... Quan Wei42041271
打开 PubMed

发现 2026-04-28

出版 2026-01-01

Frontiers in gastroenterology (Lausanne, Switzerland)
Tangled contacts: mitochondrial interactions with cellular organelles in acute pancreatitis.
Serge Chooklin, Serhii Chuklin42038531
打开 PubMed

发现 2026-04-28

出版 2026-01-01

Frontiers in neurology
C-reactive protein to albumin ratio as a novel predictor of stroke-associated pneumonia: a retrospective cohort study revealing non-linear threshold effects.
Tingting Duan, Changwei Zou, Ming Yang, ... Zhaoping Wu42037696
打开 PubMed

发现 2026-04-28

出版 2026-01-01

Surgical case reports
Massive Pancreatic Pleural Effusion Caused by Intrathoracic Perforation of a Pancreatic Pseudocyst Successfully Managed with Endoscopic Drainage Followed by Thoracoscopic Decortication: A Case Report.
Makoto Hirai, Hiroki Ebana, Kohei Tagawa, Aki Kobayashi42040504
打开 PubMed

发现 2026-04-27

出版 2026-04-24

Journal of hepatology
Tim-3 facilitates dendritic cell ferroptosis and impairs anti-tumor immunity in steatohepatitis-related HCC.
Na Li, Xiaojia Song, Xueqi Peng, ... Chunhong Ma42035954
打开 PubMed

发现 2026-04-27

出版 1993-01-01

GeneReviews
Pancreatitis Overview
Authors: not available24624459
打开 PubMed

发现 2026-04-27

出版 2026-12-31(期刊卷期日期)

Gut microbes
EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis.
Maria L Orsini Delgado, Camille Baudesson de Chanville, Hélène Pfister, ... Antonietta Cultrone42033239
打开 PubMed

发现 2026-04-27

出版 2026-12-31(期刊卷期日期)

Gut microbes
An oral-gut microbial metabolite linksto aggravated myocardial ischemia-reperfusion injury.
Yiwen Li, Qian Xu, Mengmeng Zhu, ... Yue Liu42033241
打开 PubMed